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6 Compared with placebo, semaglutide has been shown to result in greater improvements in cardiometabolic risk factors such as waist circumference, blood pressure, lipid levels, and A1C levels
CagriSema (semaglutide + cagrilintide), filed by Novo Nordisk in December 2025, achieved 22.7% weight loss in trials and could receive FDA approval in 2026
the reconstituted vial holds ~5 mg/mL
Research suggests that GLP-1 receptor agonism may reduce the production of pro-inflammatory cytokines, decrease oxidative stress, and potentially influence the balance between pro-inflammatory and regulatory T cell populations
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