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Adequate fluid intake helps fiber do its job by softening the stool and preventing constipation, which is especially important when your appetite is suppressed, says Salhab

, including Clostridium butyricum , produce butyrate, which helps to maintain gut epithelial cells and has anti-inflammatory properties [3235]

But when you combine glucagon receptor agonism with strong GLP-1 and GIP activity, something interesting happens: GLP-1 and GIP's insulin-stimulating effects offset glucagon's glucose-raising tendency, and what's left is glucagon's other effects increased hepatic energy expenditure, upregulated fatty-acid oxidation, and thermogenesis