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Abstract Background: With the continuously increasing incidence of type 2 diabetes, glucagon-like peptide-1 (GLP-1) receptor agonists, known for their dual benefits of effectively controlling blood glucose levels while also reducing weight and lowering cardiovascular disease risks, have been widely employed in the treatment of this condition

This dual-mechanism approach enables more pronounced and sustained growth hormone secretion than either peptide administered individually, while preserving the natural pulsatile pattern of growth hormone release that maintains physiological feedback mechanisms