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Post hoc analysis of its placebo-controlled trial in patients with non-alcoholic steatohepatitis (NCT00227110) demonstrated that pioglitazone reduces hepatic/visceral fat and improves necrosis and inflammation (113)
What Actually Happens to Your Face When You Lose Weight on GLP-1s The face is organized around a series of fat compartments, called fat pads, that give it its three-dimensional structure
What to monitor: The same factors as the 1 mg phase, plus blood glucose patterns if you monitor them, hydration status (GLP-1 agonists can reduce thirst cues), and mood or energy shifts that may indicate metabolic transition
Patients should receive comprehensive education about proper injection technique, dose timing, storage requirements, and what to do if doses are missed
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