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The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)
But thats far from the truth
Variations in SLC2A9 gene, encoding the urate transporter GLUT9, are closely related to human cognition and neurodegenerative diseases ( Urate Transporters and Genetics of Urate Transporter Pathologies A series of urate transporters including SLC and ABC transporters as well as several multispecific drug transporters (e.g., OAT1, OAT2, and ABCG2) maintain UA homeostasis (Figure 2) (Tomita et al., 2000
CASP1, Caspase 1
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