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S-adenosylmethionine acts as a universal methyl donor for several reactions, being the major biological methylating agent ( Before producing methylation potential, Met may also play an indirect role in polyamine (putrescine, spermidine, and spermine) synthesis ( Figure 1 )

A Fenton reaction catalyzed by Fe 2+ and H 2 O 2 also produces the hydroxyl radical (116)

Similarly, in an article published in Muscle and Fitness, glutathione combined with L-citrulline boosted nitric oxide production (NO) better than placebo or L-citrulline alone.20 Nitric oxide is well known to dilate blood vessels improving blood flow and oxygen delivery to muscles and tissues

As outlined above, studies on non-glutathione disulfide substrates unfortunately regularly lack more detailed kinetic analyses, first, to confirm the efficient turnover of the substrate candidates and, second, to validate the dithiol mechanism