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The use of antioxidant supplements such as N-acetylcysteine (NAC), could also help to decrease oxidative stress, as they prevent the proapoptotic effect due to oxidative and nitrosative damage generated by increased tryptophan catabolites or increased NOX2 activity [327]
The system uses a gradient of aqueous and organic solvents to separate the peptide
1), thus decreasing its availability in blood [328, 329]
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