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Contact your GP or healthcare provider if: Hot flushes are severe, persistent, or significantly impacting your daily activities and quality of life You experience hot flushes accompanied by other concerning symptoms such as chest pain, palpitations, shortness of breath, dizziness, or fainting You notice unexplained weight loss (beyond what is expected with Mounjaro), night sweats, fever, or fatigue, which could indicate an underlying medical condition Hot flushes are associated with signs of hypoglycaemia such as tremor, confusion, sweating, or hungertreat low blood glucose immediately with fast-acting carbohydrate (e.g., glucose tablets, fruit juice), recheck your levels after 15 minutes, and seek help if symptoms don't improve You develop new or worsening symptoms that you believe may be related to your medication You experience severe, persistent abdominal pain (with or without vomiting), which could indicate pancreatitis You develop symptoms of gallbladder disease such as pain in the upper right abdomen, fever, or jaundice Call 999 immediately if you experience severe chest pain, signs of a heart attack or stroke, or severe breathlessness

Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities