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Brainstem : The area postrema, nucleus tractus solitarius, and dorsal motor nucleus of the vagus contain both GLP-1-producing neurons and GLP-1 receptors

Therefore, repeated-dose carnitine supplements only modestly increase the plasma L-carnitine concentration in muscular tissue even when very high oral doses are administrated, (i.e., more than 2 g per day) [14]

Some models report measurable pathway changes within days, while others require longer observation periods

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