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What Clinical Trials Reveal Large randomized trials and meta-analyses have confirmed semaglutides cholesterol benefits: Total cholesterol: down 46% LDL cholesterol: down about 5% Triglycerides: down 1518% HDL cholesterol: small increase The landmark trial found that semaglutide reduced the risk of heart attack, stroke, or cardiovascular death by about 20%

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With several domestic pharmaceutical companies preparing to launch branded generic formulations, millions of patients may soon gain access to effective weight-loss therapy