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This peptide is the active ingredient in the topical copper peptides that have been sold as cosmetic agents on the dermatology shelf since the late 1980s, with the caveat being that topical GHK-Cu needs to penetrate the stratum corneum layer of skin before getting to the dermis, which houses the receptors for the peptide

[81] [82] It offers a rational way to investigate the pathogenesis of complex disease phenotypes in general, in which many loci invariably contribute to susceptibility or resistance to disease, and disease occurs in those individuals with an unfavorable imbalance between these opposing influences

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