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GSH has a free electron it can donate to reactive oxygen species, such as free radicals, to neutralize them, thus preventing them from damaging cells

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Instead, it is more appropriate to envision metabolic plasticity regarding uptake of alternative metabolic substrates and promotion of metabolic rewiring as a built-in feature that has evolved to allow cancer cells to constantly adapt to changing intracellular- and extracellular metabolic conditions 2

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