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Among the participants, 1,320 had pre-diabetes at the start of the study, defined by blood sugar levels between 5.7%-6.4%
This allows NCC to be transported to the membrane where it can participate in Na + and Cl transport leading to increased Na + reabsorption in the DCT
As the second line of defense, it is considered to be an effective antioxidant that can penetrate cell membranes and concentrate within mitochondria to modulate mitochondrial function by interacting with mitochondrial MT1 receptors [38, 39], and many of its reaction products and metabolites (e.g., 6-hydroxymelatonin) also have antioxidant activity [40, 41]
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