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Testing may include SAM, SAH, methionine, homocysteine, whole-blood histamine, copper, zinc, ceruloplasmin, urinary pyrroles, organic acids, lactate, pyruvate, glutathione-related markers, 8-OHdG and lipid peroxides when clinically appropriate

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Effect of RYBELSUS Formulation: There were no clinically significant differences observed in the mean steady state AUC0-24h,SS and Cmax,SS between the 3 mg, 7 mg and 14 mg doses of RYBELSUS (formulation R1) and the 1.5 mg, 4 mg and 9 mg doses of RYBELSUS (formulation R2), respectively, in a clinical study conducted in healthy subjects