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Understanding common side effects 1 The most common adverse reactions, reported in 5% of patients treated with RYBELSUS are: nausea abdominal pain diarrhea decreased appetite vomiting constipation In the pool of placebo-controlled trials, the majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation
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Persistent vomiting or diarrhea can lead to dehydration and kidney problems, which may show up as reduced urination, back pain, or swelling in the legs or ankles
However, GSH has an overall negative charge at physiological pH, and mitochondria also exhibit an enormous negative membrane potential [57, 58]
