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Constipation from GLP-1 Medications: Functional Medicine Solutions for Relief GLP-1 receptor agonists such as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound) are transforming the treatment of obesity, insulin resistance, and type 2 diabetes

The fatty-acid structure surrounding semaglutide might have prevented it from being able to penetrate certain brain regions, such as the hippocampus, which controls memory and cognitive function

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The triple agonist produced significantly greater normalization of liver enzymes (ALT, AST) and inflammatory markers