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Both antibodies are effective in treating relapsed/refractory MM and can be used in combination with other therapies 148,149
This is to avoid serious health issues
Hence, the described CEACAM-1 renal effects can be due to the lack of its expression as well as the observed hyperinsulinemia ( Despite early conflicting results, further studies showed that insulin is excreted in urine
One of the reasons is that their symptoms appear to be significantly intertwined, causing difficulty in diagnosing a patient with one condition or the other
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