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Glucagon receptor activation, the third arm of Retatrutides mechanism, primarily affects energy expenditure and metabolism

[11] [12] Other key factors include: Dose level : Higher doses (e.g., 12 mg in trial protocols) produced greater weight loss than lower doses, though they were also associated with a higher incidence of gastrointestinal side effects

Baseline demographic characteristics, baseline HbA 1c , body mass index (BMI), and estimated glomerular filtration rate were derived from the SUSTAIN China trial [23]