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Semaglutide is a peptide that is broken down in the stomach and intestines, not absorbed intact

The potential of GLP-1RAs to induce psychiatric adverse events is biologically plausible given the widespread expression of GLP-1 receptors in the central nervous system, 167 their influence on neurocognitive function, 168 and their effects on inflammation, stress response, and energy metabolism, which theoretically could improve mood