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All injections were performed under general anesthesia using ultrasound guidance by a trained physiatrist under sterile conditions

127,128 Target at subchondral bone The therapeutic targets of most of todays OA research are the articular cartilage itself, it is worthwhile to include the search of novel targets in the subchondral bone, which markedly becomes thicker and disrupted the mechanical stability in OA joints

Since rheumatoid arthritis is an autoimmune disease meaning the body is working against itself many of the treatment options can seem limited to pain reduction, rather than helping the body get its immune balance back in shape

As neurons lack the enzyme pyruvate carboxylase and therefore cannot synthesize glutamate through the TCA cycle [18], they rely on astrocytes for the generation of glutamate