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Introduction A marked rise in the global prevalence of obesity and associated metabolic pathologies has been observed over the past 30 years ( Globally, more than 1 billion people are estimated to have NAFLD, including 83 million patients in the United States, making NAFLD the most common chronic liver disease in the US ( NASH is diagnosed histologically, based on the extent of steatosis, hepatocyte stress and damage (hepatocyte ballooning), immune infiltration (lobular inflammation), and degree of fibrosis ( While late-stage NASH greatly increases the risk of liver-related morbidity, NAFLD and NASH with less advanced fibrosis (i.e., F0F2) are associated with greatly increased risk of cardiovascular disease and related mortality ( Despite the unmet medical need, there is currently no approved therapy for NASH

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Available online at: August 11, 2025) A Randomized, Double-Blind, Placebo Controlled, Parallel Groups Study on Efficacy and Safety of nac 600 mg Daily and nac 1200 mg Daily as Mucolytic Agent in the Treatment of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
