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In pharmacokinetic studies across multiple animal modelsincluding oral administration in mice and Sprague-Dawley (SD) rats, as well as oral and injectable administration in beagle dogs and cynomolgus monkeysCompound 282 exhibited outstanding metabolic stability
10.1016/j.cmet.2011.02.001 182
[24] [25] Individuals with MEN 2 carry germline RET mutations conferring near-100% lifetime risk of developing MTC, often presenting in childhood or early adulthood
Steinbrenner et al., 2006), testicular Leydig cells (Koga et al., 1998), adipocytes (Zhang and Chen, 2011), and -cells of the pancreas (Steinbrenner et al., 2013), at least in vitro
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