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IUPHAR/BPS Guide to Pharmacology

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By coupling agonism at the GLP-1 receptor with simultaneous agonism at the GIP receptor, a related incretin whose physiological role had been the subject of decades of competing theories, Eli Lilly produced a molecule whose efficacy in trial conditions exceeded semaglutide by a margin too large to dismiss as noise or trial-design artifact

Retrieved November 9, 2021 from Urbanski, G., Hamel, J.-F., Prouveur, B., Annweiler, C., Ghali, A., Cassereau, J., et al