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Description

The 'DAC' (Drug Affinity Complex) in some formulations of CJC-1295 refers to a modification that extends its half-life, allowing for less frequent dosing and more stable GH levels

doi: 10.1016/j.jep.2017.08.032 251 ShinW.YoonJ.OhG

In the central nervous system, GLP-1 RAs can either directly cross regions with a compromised blood-brain barrier or act via vagal afferent signaling to target GLP-1 receptors (GLP-1Rs) in the nucleus tractus solitarius (NTS) of the brainstem