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Professor Giovanna Traina from the University of Perugia explained via email to GMFH editors that a healthy intestinal barrier is essential for the maintenance of gastrointestinal health, but also for the systemic health of the host, as it is able to preserve the potential translocation of bacteria, food allergens, xenobiotics and inflammatory mediators in the systemic circulation, that may compromise the functionality of other organs. Such a defect in the gut barrier may facilitate dietary and microbial antigen influx, leading to the chronic inflammation involved in the onset of modern diseases

The logic follows: reduce inflammation, improve metabolism, lose weight

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In the past three decades, however, diversity in clinical trials became a policy priority, advanced by federal agencies such as the Food and Drug Administration (FDA) Office of Womens Health and the Society for Womens Health Research (SWHR), and later by the FDA Office of Minority Health (OMH), established in 2010 (FDA, 2011)