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In both instances, the drug was to be used as part of a broader weight management program in conjunction with a reduced-calorie diet and increased physical activity
Conversely, in cellular contexts dependent upon Parkin-mediated mitophagy for survival, interference with this pathway via MST1-p53 axis activation or FFAR2/PPAR- signaling blockade enhances cellular susceptibility to ferroptosis upon Erastin treatment
For a powerful class of drugs known as "biologics," delivering medicine in a pill was an extremely challenging scientific puzzle for almost a century
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