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However, common reasons to take BHRT include individuals that are: Experiencing midlife transitions, such as with perimenopause or menopause Having cognitive symptoms that are linked to hormone imbalances or stress Demonstrating persistent brain fog or mood symptoms despite having normal labs Regardless of the scenario, BHRT should always be coupled with a holistic strategy that further augments cognition and mental health

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iScience 28 , 113474 (2025)

Why are there so many different protocols