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Phase II: Conjugation Reactive intermediates from Phase I are bound to endogenous molecules, becoming water-soluble and less toxic

Benefits Beyond Weight Loss: Metabolic and Cardiovascular Health Cardiovascular risk reduction semaglutide reduced major cardiovascular events by 20% in the SELECT trial Blood sugar control significant HbA1c reductions in patients with type 2 diabetes or prediabetes Reduced liver fat growing evidence supports GLP-1 therapy for NAFLD and MASLD Sleep apnea improvement tirzepatide demonstrated 63% reduction in apnea-hypopnea index (2024 NEJM trial) Fatty Liver Disease & GLP-1 Therapy Patients with NAFLD/MASLD may see significant improvement with GLP-1 treatment

It is given in cases where oral administration is not possible

doi: 10.1007/s11154-017-9407-2 20 EickmanKMaxwellRMcGinnisLKStanczykFLegroRLindheimSR