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However, while early indications are promising, clinical trials and long-term studies are required to confirm the safety and effectiveness of this combination
Animal studies indicate fetal growth restriction, ossification delay, skeletal variants, and reduced maternal weight gain, though more recent human evidence, including a 2024 cohort of 938 pregnancies, suggests no increased risk of major congenital malformations compared with insulin
Microdose tirzepatide may be a good fit for patients who want a gentle dual-pathway option, are concerned about side effects, have previously experienced nausea on GLP-1 medications, or want gradual weight management support
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