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The resulting PBPK model for metformin in humans includes 21 tissues and body fluids compartments and can simulate metformin concentration in the stomach, small intestine, liver, kidney, heart, skeletal muscle adipose, and brain depending on the body weight, dose, and administration regimen

85 4.5 General Treatment Considerations 4.5.1 General Principles That Apply to the Medical Management of Obesity Comprehensive treatment of obesity is multimodal