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Eighteen 4-5-week-old female BALB/c nude mice were purchased and housed in an animal house (SPF grade), divided into 3 groups of 6 mice each, which were the TPC-1 cell-negative control group (n=6), the experimental group injected with RRM2 -KD cells (n=6), and the experimental group injected with RRM2 -OE cells (n=6)

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