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Thus, its potential value as a therapeutic agent has greatly diminished [4, 5]
When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2
Research in older populations The majority of human research on epitalon has been conducted in elderly populations, typically ages 60 to 80
Souza JGS, Bertolini M, Thompson A, Mansfield JM, Grassmann AA, Maas K, et al
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