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Gastrointestinal side effects are well-documented with GLP-1 therapy and may indirectly affect fluid balance

By promoting insulin secretion and reducing glucagon, semaglutide helps stabilize blood sugar levels, which can prevent spikes and crashes that often lead to increased hunger and overeating

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In addition, serine metabolism to cystathionine, cysteine, and GSH as traced with 13 C 3 -serine showed no detectable GSH biosynthesis from the TSS pathway (Supplementary Fig