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At the level of gene transcription, the fact that three different proteins can be synthesized from gpx4, due to the presence of multiple transcriptional start sites, yielding the mitochondrial (m-), nuclear (n-), and cytosolic (c-) GPx4 forms, makes the issue of gene regulation extremely complex 54
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Ultimately, 10% to 30% of patients with LN progress to end stage renal disease requiring renal replacement therapy even with our current immune targeted therapies1,2
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