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Psychiatric Adverse Events The first pharmacovigilance signal suggesting a potential association between GLP-1 receptor agonists and psychiatric adverse events emerged from an EudraVigilance analysis initiated following the European Medicines Agencys regulatory review, in response to reports of mood changes and suicidality

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Documented evidence, such as a diagnosis from a doctor or an A1C result of 6.5 or above, is required for a prescription