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As with other GLP-1-based therapies, the most frequently reported side effects of retatrutide particularly during the initiation and dose-escalation phases are gastrointestinal in nature

The authors hypothesized that early life adversity may alter oral microbiome composition, which can shift to gut via saliva, potentially creating a pro-inflammatory state that increases vulnerability to PTSD following subsequent trauma exposure (Malan-Muller et al., 2022)

Recent studies, such as the SUSTAIN trial, have indicated promising cardiovascular benefits associated with Semaglutide use

Some patients benefit from periodic "tune-up" courses of GLP-1 medication if they experience significant weight regain despite lifestyle efforts