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Wadhawan, S

A systematic review and meta-analysis of serum phosphorous levels and the progression of CKD showed an association between elevated phosphorous levels and an increased risk of kidney failure, along with higher mortality in patients with CKD

These are considered an alternative treatment to metformin, as their function lies in the modulation of the components that signal the insulin pathways, thus influencing processes such as the regulation of the menstrual cycle, carbohydrate metabolism, and hyperandrogenism

It summarizes published pharmacology, clinical-trial dosing context, and common protocol planning patterns