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Nystrom, T., Gonon, A
Fundamentally, aging is driven by the cumulative effects of cellular senescence (Suter et al., 2025)
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The cysteinyl sulfur of glutathione (GSH) is maintained in the reduced state by NADPH produced in the oxidative phase of the pentose phosphate shunt and provides a nucleophilic thiol important for the detoxification of electrophilic metabolites and metabolically-produced oxidizing agents
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