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After 12 months of treatment, compared with those on semaglutide alone, women who were taking both MHT and semaglutide: showed an improved weight loss response achieved about 30% more total body weight loss The reasons for this association are unknown, though the authors propose that it may be due to MHT improving other quality of life measures
Bianchi et al
Some practitioners have theorised that in men with elevated oestrogen levels (hyperestrogenism), reducing oestrogen through aromatase inhibition might improve the testosterone-to-oestrogen ratio and potentially benefit sexual function
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