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Caprelsa was first approved in 2011, with REMS requirements to ensure safe use due to potential heart rhythm risks
Haslam DW, James WPT
Finally, following recent concerns by regulatory agencies regarding a potential increase in suicidal behavior associated with GLP-1RAs 206 , we found 1 recent pharmacovigilance report showing 0.6% suicidal events among 41,236 safety reports for these medications 207 and an emulated target trial of 86,418 older adults with T2DM that did not identify any difference in suicidal ideation or behavior between GLP-1RAs and other antidiabetic medications over 1.5 years 208
3, 6 This multi-target approach represents a fundamental shift in how we think about treating Alzheimers
