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Calcium and magnesium can help with muscle cramps
Short non-diabetic data support remaining at 2.5 mg when weight and insulin-resistance markers are already moving and tolerability favors a hold. The label still positions 2.5 mg as the starter before 5 mg, so it is a defensible low-dose floor for selected users rather than a replacement for the 5 mg obesity-trial floor
Protects tissues from ischemia-reperfusion injury
Pickarts data shows that levels drop about 60% by age 60
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