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Key variants like MC4R rs17782313 influence how your body responds to tirzepatide and may inform whether supplementation like creatine aligns with your metabolic profile

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While publication bias cannot be entirely excluded, a comprehensive search strategy across multiple databases was used to minimise this risk

Additional testing may be considered for people with a family history of premature heart disease, metabolic risk, abnormal cholesterol results, known cardiovascular disease, or uncertainty after standard testing: ApoB, Lp(a), and hs-CRP may help reveal particle burden, inherited risk, and inflammation that are not fully captured by LDL cholesterol alone