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Weill Professor of Metabolic Research at Weill Cornell Medicine in New York and lead author of the post hoc analysis, told Healio

Creative Commons CC-BY license, Obesity is associated with numerous health complications, including type 2 diabetes, cardiovascular disease, metabolic dysfunction-associated steatotic liver disease (MASLD), and certain cancers

[6] Pharmacodynamic synergy with other carbonic-anhydrase inhibitors (acetazolamide, zonisamide) amplifies the risk of metabolic acidosis and nephrolithiasis, while combined use with valproate has been repeatedly implicated in hyperammonemic encephalopathy even at therapeutic serum valproate levels