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This guidance clarifies the need for developers to explicitly define context of use and demonstrate that a NAM is biologically relevant, technically robust, and fitforpurpose to support regulatory decisionmaking within that context

Boosts Energy and Reduces Fatigue Iron helps carry oxygen in the blood, improving stamina and reducing tiredness B12 supports energy metabolism and nerve health 4

A growing body of work suggests GLP-1 drugs act on platelets, immune cells, and vascular cells to protect against atherosclerosis independently of their effects on glycemia, appetite, and weight