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Overall, the ADJUNCT programme demonstrated dose-dependent improvements in HbA 1c , a decrease in the daily insulin dose and a reduction in body weight with liraglutide compared with placebo
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We matched subjects 1:1 on the logit transformation of the propensity score by nearest-neighbor (greedy) matching without replacement, using a caliper width equal to 0.2 x the (pooled) SD of the transformed propensity scores (42, 43)
Realistic expectations regarding weight loss magnitude (typically 10-15% of body weight with higher-dose formulations) and the importance of concurrent lifestyle modification should be established before initiating therapy
