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FIGURE 9 Discussion Hyperglycemia-induced chronic inflammation and metabolic dysregulation play a crucial role in the micro- and macro-vascular complications of diabetes and are associated with long-term dysfunction of various organs, especially the liver and kidneys ( Despite the benefits of pharmacological therapies, prophylactic approaches such as physical exercise, besides caloric restriction are considered the cornerstone in the management of type 2 diabetes ( Our previous study in GK rat pancreas demonstrated exercise-induced beneficial effects by improving energy metabolism, antioxidant responses and mitochondrial functions, and metabolic adaptation (Raza et al., 2016)

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This brings us to the pivotal question: how can we effectively absorb glutathione, especially when considering supplementation

al.) Persistent excessive drinking leads to chronic inflammation in the liver, which is known as alcoholic hepatitis