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The percentage of adults achieving an HbA1c of less than 7% at 32 weeks was 89.3% in the combination therapy group, 69% in the semaglutide group and 33.3% in the cagrilintide group
This is likely due to a reduction of peptide interactions (mainly A5 Cagri ) with ECL3 that is a consequence of the engagement of the lipidated N-terminus with the top segment of TM5/ECL2, facilitating flexibility of ECL3
doi: 10.3389/fmed.2026.1698091 Received 03 September 2025 Revised 16 March 2026 Accepted 19 March 2026 Published 20 April 2026 Volume 13 - 2026 Edited by Liliana Gabriela Popa, Carol Davila University of Medicine and Pharmacy, Romania Reviewed by Manoj B
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