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However, combined efficacy and safety have only been examined in preclinical models, not in controlled human trials, so any pairing exists strictly within Research Use Only parameters
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In guinea pig models in vivo, confirmed in silico analysis, as mitigation of allergic rhinitis symptoms including sneezing and rubbing, and reductions in serum levels of IL-17, IL-6, TNF-, and IL-1 were observed upon BBR treatment (50 and 100 mg/kg) [56]
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