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Overall, current data substantiates a strong mechanistic rationale and an early clinical signal for natural compounds in ASD, especially in subgroups with oxidative or mitochondrial dysfunction or nutritional deficits

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NAD+ plays a significant role in activating certain enzymes to repair DNA damage that occurs because of stress, aging, and environmental factors

The results of these randomized, placebo-controlled studies showed that intravenous lipoic acid could improve endothelial function in patients with impaired fasting glucose (64) or impaired glucose tolerance (65)