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Semaglutide was initiated at 0.25 mg per week for the first 4 weeks via a pre-filled pen injector, escalating in a fixed-dose regimen every 4 weeks to reach the maintenance dose of 2.4 mg by week 16 (lower maintenance doses were permitted if participants were unable to tolerate 2.4 mg) (Extended Data Fig
In addition to selling the full semaglutide molecule, the company also markets different parts of the compound, such as individual amino acids and a fatty side chain that can be attached to the peptide to increase the drugs half-life in the body
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